Advertising or giving away PROMETHAZINE WITH CODEINE ORAL SOLUTION may possibly harm Other individuals, which is from the legislation. Notify your healthcare company When you have ever abused or been dependent on Liquor, prescription medicines or street medicine.
The concomitant usage of Promethazine HCl and Codeine Phosphate Oral Solution with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may possibly cause decreased codeine levels, increased norcodeine ranges, and less metabolism via 2D6 with resultant lower morphine levels.
Take this medication just as prescribed to decreased the risk of dependancy. Request your doctor or pharmacist for more specifics.
On account of comparable pharmacologic properties, it can be realistic to expect related threat with concomitant usage of opioid cough medications and benzodiazepines, other CNS depressants, or Liquor.
Dosing The dose of this medicine will likely be diverse for various clients. Observe your physician's orders or even the directions around the label. The following information and facts consists of only the average doses of the medication. When your dose is different, don't alter it Until your health practitioner lets you know to take action.
A Health care Experienced really should be consulted in advance of getting any drug, transforming any diet regime or commencing or discontinuing any program of treatment.
Opioids are sought by drug abusers and folks with habit Conditions and they are issue to criminal diversion. Consider these dangers when prescribing or dispensing Promethazine HCl and Codeine Phosphate Oral Solution. Approaches to scale back these challenges involve prescribing the drug in the smallest appropriate quantity and advising the affected person on the correct disposal of unused drug [see Affected person Counseling Facts (seventeen)].
Tend not to choose this medication for several days in advance of allergy testing for the reason that test final results is usually impacted.
Often use an correct milliliter measuring product when administering Promethazine HCl and Codeine Phosphate Oral Solution in order that the dose is measured and administered accurately. A household teaspoon isn't an accurate measuring gadget and could lead to overdosage [see Warnings and Safeguards (5.
If Promethazine HCl and Codeine Phosphate Oral Solution is useful for a chronic period in a very pregnant female, suggest the affected person of the potential risk of neonatal opioid withdrawal syndrome and be sure that proper treatment are going to be offered [see Warnings and Precautions (five.20)].
In animal copy reports, codeine administered with the oral route to pregnant rats throughout the period of organogenesis enhanced resorptions and lowered fetal weights at a dose roughly 25 times the maximum advisable human dose (MRHD) in the existence of maternal toxicity (see Info).
Never utilize a residence teaspoon to measure your medication. You could possibly accidentally get excessive. You'll be able to request your pharmacist for your measuring gadget you need to use and how to evaluate the proper dose.
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Promethazine Carcinogenicity studies were done with promethazine hydrochloride. Two-calendar year research in F344/N rats and B6C3F1 mice ended up carried out to evaluate the carcinogenic opportunity of promethazine hydrochloride. No evidence of tumorigenicity was noticed in male and feminine rats at promethazine hydrochloride oral doses as much as 33 mg/kg/working day for five days/7 days (somewhere around reminiscent of 10 times the MRHD over a mg/m 2 foundation).